And it all started so well for Massimiliano Allegri’s side: Cristiano Ronaldo met Miralem Pjanic’s corner in the 28th minute of the game to score his 13th UEFA Champions League quarter-final goal and put Serie A leaders in front.
But the lead only lasted six minutes as Van de Beek slotted in the equalizer after Hakim Ziyech’s shot deflected into his path.
Ajax dominated the game in the second half and completed the comeback when De Ligt’s header from Lasse Schoene’s corner left Wojciech Szczesny helpless.
De Ligt became the youngest Dutch player to score in a UEFA Champions League knockout match since 1996.
Elsewhere on Tuesday night, Lionel Messi’s first-half double and Philippe Coutinho’s spectacular long-range strike midway through the second half led Barcelona past Manchester United and into the Champions League semi-final.